If you always feel tired, weak, or are losing weight, ask your health care professional if you might have adrenal insufficiency. Sometimes symptoms appear for the first time during adrenal crisis. This darkening is most visible on scars skin folds pressure points such as the elbows, knees, knuckles, and toes lips and mucous membranes such as the lining of the cheek.īecause symptoms of adrenal insufficiency come on slowly over time, they may be overlooked or confused with other illnesses. People with Addison’s disease may also have darkening of their skin.
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